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Get 24-hour relief from frequent heartburn with Nexium 24HR Tablets. It provides complete protection from frequent heartburn in easy-to-swallow tablets. Nexium 24HR tablets work by blocking acid directly at the source, giving you 24 hours of protection from frequent heartburn. Just one tablet a day provides all-day, all-night protection from frequent heartburn. Nexium 24HR is the #1 Selling OTC frequent heartburn brand.