Amoxicillin and Clavulanate Potassium 500 mg/125 mg Tablets 20/Bottle (Rx)
(Note: We don’t Fill Personal Prescriptions)
How to Order:
Amoxicillin and Clavulanate Potassium 500 mg/125 mg Tablets are used to treat a wide range of bacterial infections. This combination antibiotic includes amoxicillin, a penicillin, and clavulanate potassium, a beta-lactamase inhibitor, which helps overcome bacterial resistance. It is particularly effective for respiratory tract infections, sinus infections, urinary tract infections, skin infections, and ear infections. By inhibiting bacterial cell wall synthesis while neutralizing resistance mechanisms, it provides broad-spectrum antibacterial activity. These tablets are often prescribed when bacteria may be resistant to amoxicillin alone.
Amoxicillin and Clavulanate Potassium Tablets, provided by Teva Pharmaceuticals, combine two active ingredients: amoxicillin, a broad-spectrum penicillin antibiotic, and clavulanate potassium, a beta-lactamase inhibitor. This formulation is used to treat a variety of infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and skin infections. Each tablet contains 500 mg of amoxicillin and 125 mg of clavulanate potassium, and they are packaged in boxes of 20 tablets.
Details and Features
Active Ingredients:
-
Amoxicillin (500 mg) – a penicillin-type antibiotic.
- Clavulanate Potassium (125 mg) – a beta-lactamase inhibitor that extends the antibiotic spectrum of amoxicillin by blocking bacterial enzymes that might ordinarily degrade the antibiotic.
Packaging: 20 tablets per box.
Formulation: Oral tablet.
Indications: Effective against a range of bacterial infections, notably those caused by beta-lactamase-producing organisms resistant to amoxicillin alone.
Administration: Oral administration, usually prescribed to be taken at the start of a meal to enhance absorption and reduce the likelihood of gastrointestinal disturbances.
Mechanism of Action
Amoxicillin functions by inhibiting the synthesis of bacterial cell walls. It targets the penicillin-binding proteins located inside the bacterial cell wall, thereby weakening the wall and leading to cell lysis and death.
Clavulanate Potassium is a beta-lactamase inhibitor that counteracts the resistance exhibited by some bacteria. Clavulanate does this by binding to and inactivating beta-lactamase enzymes, which could otherwise degrade cephalosporins and penicillins, including amoxicillin.
Warnings
-
Allergic Reactions: Contraindicated in patients with a history of serious hypersensitivity reactions (e.g., anaphylaxis) to beta-lactam antibiotics, such as penicillins or cephalosporins.
-
Liver Monitoring: Occasional severe hepatic dysfunction (liver injury, jaundice) has been reported. Monitoring recommended for patients with hepatic impairment or those on prolonged treatment courses.
-
Renal Impairment: Dose adjustments may be necessary for patients with kidney dysfunction.
- Clostridium difficile-associated Diarrhea (CDAD): May occur with antibiotic use, including amoxicillin/clavulanate. Consider this diagnosis if diarrhea occurs during or after treatment.
Side Effects
Common side effects may include:
-
Gastrointestinal Issues: Nausea, vomiting, diarrhea, and abdominal pain. Taking the medication with food can help minimize these effects.
- Skin Reactions: Rash, itching, or skin redness. Allergic skin reactions are possible and should be reported to a healthcare provider.
Serious side effects (seek medical attention) may include:
-
Severe Allergic Reactions: Signs include difficulty breathing, hives, and swelling of the face, lips, tongue, or throat.
-
Liver Dysfunction: Symptoms of jaundice, such as yellowing of the skin or eyes.
-
Hematologic Effects: Rare cases of blood dyscrasias such as thrombocytopenia, leukopenia, or anemia.
- Severe Diarrhea: Indicative of potential CDAD.
Other Considerations
Drug Interactions: May interact with anticoagulants (increased INR or bleeding risk) and oral contraceptives, advising alternative contraceptive measures.
Storage: Store at room temperature away from moisture and heat.
Amoxicillin and Clavulanate Potassium Tablets provide a powerful combination for treating resistant bacterial infections due to their synergistic properties. Patients should adhere strictly to prescribed doses to optimize therapeutic outcomes and minimize resistance development. Always follow medical guidance and report any side effects early.