Methotrexate Sodium Injection 25 mg/mL Multi-Dose Vials 2 mL x 5/Pack (RX)

Methotrexate Sodium Injection is a chemotherapy agent and immune system suppressant utilized for various medical conditions. Below are the detailed product information and descriptions for Methotrexate Sodium Injection provided in multi-dose vials by Pfizer Injectables.

Active Ingredient:

Methotrexate Sodium: Each mL of the injection contains 25 mg of methotrexate, a folate analog metabolic inhibitor.

Concentration: 25 mg/mL

Formulation:  Injectable solution

Packaging:

- Volume: 2 mL per vial
- Presentation: Supplied as multi-dose vials in packs of five.

Indications:

• Oncology: Methotrexate is primarily used for the treatment of certain types of cancer, including breast cancer, leukemia, lymphoma, osteosarcoma, and lung cancer.
  
• Rheumatology: Used in lower doses to treat autoimmune diseases such as rheumatoid arthritis, psoriasis, and juvenile idiopathic arthritis.
  
• Others: Sometimes indicated for ectopic pregnancies or used in combination with other chemotherapy agents.

Mechanism of Action:

Methotrexate inhibits dihydrofolate reductase, interfering with DNA synthesis, repair, and cellular replication. This is especially effective in actively proliferating tissues such as malignant cells, bone marrow, and skin epithelium.

Administration:

• Route: Usually administered via intravenous, intramuscular, subcutaneous, or intrathecal injections, depending on the specific clinical situation and doctor’s guidance.
  
• Dosage: Determined by medical condition being treated, patient age, weight, and response to therapy. Dosage adjustments may be necessary.

Safety and Precautions:

• Contraindications: Known hypersensitivity to methotrexate or any component of the injection. Not to be used during pregnancy due to teratogenic effects.
  
• Warnings and Precautions: Closely monitor blood counts, liver function, and renal function. Risk of bone marrow suppression, hepatotoxicity, pulmonary toxicity, and gastrointestinal toxicity. Use caution with concomitant NSAID therapy.
  
• Adverse Reactions: Possible side effects include nausea, vomiting, stomatitis, and in more severe cases leukopenia, hepatotoxicity, or nephrotoxicity.

Storage: Store at controlled room temperature, away from direct light. 

Methotrexate Sodium Injection is an essential medication for multiple therapeutic purposes across different specialties. Proper handling and administration by healthcare professionals ensure its effective and safe use tailored to individual patient needs.