Ovidrel Injection Prefilled Syringe 250 mcg (Choriogonadotropin Alfa Injection) by EMD Serono 0.5 mL **Refrigeration Required

Ovidrel Injection Prefilled Syringe contains 250 micrograms of Choriogonadotropin Alfa, an injectable hormonal medication used primarily in fertility treatments. Manufactured by EMD Serono, this product comes ready-to-use in a 0.5 mL prefilled syringe, ensuring accurate dosing and convenience for patients.

Mechanism of Action:

Choriogonadotropin alfa is a recombinant form of human chorionic gonadotropin (hCG), which mimics the naturally occurring hormone produced in pregnancy. In fertility treatments, hCG triggers final maturation and release (ovulation) of the egg from the ovary by mimicking the natural luteinizing hormone (LH) surge. 

Indications:

Ovidrel is primarily used in assisted reproductive technologies (ART) such as in vitro fertilization (IVF) and intrauterine insemination (IUI) to:

• Trigger ovulation in women undergoing ovulation induction or controlled ovarian stimulation.
  
• Facilitate the final maturation of ovarian follicles and their subsequent release.

Composition:
Each prefilled syringe contains:

• Active Ingredient: Choriogonadotropin Alfa 250 mcg
  
• Excipients: Mannitol, methionine, poloxamer, and water for injection.

Dosage and Administration:

• Dosage: The typical dose is a single 0.5 mL injection (250 mcg) administered at a specific point in the ovulation induction cycle, as directed by a healthcare provider.
  
• Administration: Subcutaneous injection, typically into the abdomen or thigh.
  
• Timing: It is crucial to follow the precise timing and instructions provided by a healthcare provider to ensure optimal treatment outcomes.

Precautions and Contraindications:

• Contraindications: Should not be used in patients with known hypersensitivity to hCG or any excipients, or in those with primary ovarian failure, uncontrolled thyroid or adrenal dysfunction, or certain types of tumors.
  
• Precautions: Medical supervision is necessary to avoid potential complications.
• Risks such as ovarian hyperstimulation syndrome (OHSS) or multiple pregnancies should be discussed with a healthcare provider.

Side Effects:

• Possible side effects include:
  
• Local reactions at the injection site (e.g., pain, redness, or swelling).
  
• Headache, fatigue, or mood changes.
  
• Symptoms of OHSS (e.g., abdominal pain, bloating, nausea).
  
• Rare but serious allergic reactions.

Storage:

• Store the prefilled syringe in the refrigerator (2°C-8°C).
  
• Protect from light and do not freeze.
  
• Allow the syringe to reach room temperature before injection.

Patient Counseling Information:

Patients should be instructed on proper self-administration techniques, including handwashing, preparing the injection site, and proper disposal of the syringe. They should be advised to seek immediate medical attention if they experience any severe or concerning symptoms.

Ovidrel Injection Prefilled Syringe 250 mcg (Choriogonadotropin Alfa Injection) is a key medication in fertility treatments, designed to aid in the final steps of ovulation induction and optimize the chances of successful conception. Adherence to medical guidance and correct administration procedures are pivotal for effective and safe use.