Sodium Bicarbonate 4.2% Injection Single-Dose Vials 5 mL x 25/Tray by Pfizer (Rx)

Sodium Bicarbonate 4.2% Injection is used to treat metabolic acidosis, a condition where the body produces excessive acid or the kidneys cannot remove enough acid, commonly seen in conditions like renal failure or diabetic ketoacidosis. It restores the body's pH balance by neutralizing excess acid in the bloodstream. Additionally, it may be used in emergency situations to manage cardiac arrest and severe hyperkalemia. Administered intravenously, it is a critical tool in acute care settings to stabilize patients quickly.

Pfizer 4.2% Sodium Bicarbonate for Injection 5 mL is a sterile, nonpyrogenic, aqueous solution of 4.2% sodium bicarbonate, USP, for intravenous administration. Each milliliter (mL) of the solution contains 42.0 mg of sodium bicarbonate, USP and Water for Injection. Sodium bicarbonate, USP is an alkalinizing agent. The pH of the solution is 7.4 to 8.6. The solution is designed to correct acidosis and to maintain the blood pH within normal limits. It is an electrolyte replenisher.

Benefits for Sodium Bicarbonate Injection:

• Sodium bicarbonate injection 4.2% single-dose vials are used as neutralizing agents. Some potential benefits may include:
• Treatment of acidosis: Sodium bicarbonate can help restore the acid-base balance in the body by neutralizing excess acid. This can be particularly beneficial for patients with certain medical conditions, such as metabolic acidosis.
• Prevention of kidney damage: High levels of acid in the blood can damage the kidneys. By neutralizing excess acid, sodium bicarbonate injection can help protect the kidneys from damage.
• Improved heart function: Acidosis can have negative effects on the heart. Sodium bicarbonate can help correct the acid-base imbalance and improve heart function.
• Relief of symptoms: Sodium bicarbonate injections can provide relief for symptoms caused by excessive acid in the body. This can include symptoms such as heartburn, indigestion, and sour stomach.
• Adjuvant therapy for cancer treatment: Some cancer treatments, such as chemotherapy, can cause acidosis. Sodium bicarbonate injections can be used as adjuvant therapy to reduce the side effects and improve the effectiveness of cancer treatments.
• Emergency treatment: Sodium bicarbonate injections can be used as an acute treatment for certain poisonings, such as aspirin overdose, by neutralizing the acidic poison.
• Easy administration: Sodium bicarbonate injections are available in single-dose vials, making them convenient to use and administer.
• Safe and effective: When used as directed and under the supervision of a healthcare professional, sodium bicarbonate injections are generally safe and effective in treating acidosis and related conditions.

Details and Features

Active Ingredient: Sodium Bicarbonate
Concentration: 4.2% (42 mg/mL)
Volume: 5 mL per vial
Packaging: 25 single-dose vials per tray
Formulation: Sterile solution for intravenous use
Usage: Treatment of metabolic acidosis, alkalization in specific drug overdoses, and in certain renal conditions
Manufacturer: Pfizer Injectables

Mechanism of Action

Sodium Bicarbonate acts as a systemic alkalinizing agent, dissociating to provide bicarbonate ions. These ions help to neutralize hydrogen ions and raise the pH of blood and urine. By increasing bicarbonate levels, it aids in reversing states of acidosis and helps to restore normal acid-base balance in the blood. It also assists in enhancing renal clearance of certain drugs by alkalinizing the urine.

Warnings

• Fluid and Electrolyte Imbalance: Use with caution in situations where there is a risk of sodium retention or fluid overload, such as renal impairment, heart failure, or hypertension.
  
• Acid-Base Imbalance: Overcorrection of acidosis can result in metabolic alkalosis.
  
• Hypocalcemia Risks: At high doses or in certain conditions, it may lead to hypocalcemia and associated tetany.
  
• Extravasation Risk: Avoid extravasation, as it may cause tissue necrosis; administer through a secure intravenous line.
  
• Pediatrics: Adjust dosage carefully in pediatrics to prevent complications related to rapid pH changes.

Side Effects

Common Side Effects:

• Injection site reactions such as pain or irritation
  
• Metabolic alkalosis if overused
  
• Edema or fluid overload, particularly in predisposed individuals

Serious Side Effects:

• Hypernatremia (high sodium levels)
  
• Metabolic alkalosis, leading to muscle twitching or cramps, confusion
  
• Hypocalcemia, potentially leading to muscle spasms or convulsions
  
• Pulmonary edema in the setting of volume overload

Administration and Monitoring

Sodium Bicarbonate 4.2% Injection should be administered by healthcare professionals experienced in managing electrolyte and acid-base disorders. Dosage must be tailored based on laboratory values and the patient's clinical condition. Continuous monitoring of blood gas, serum electrolytes, and acid-base balance is crucial during treatment to prevent complications such as alkalosis. Regular assessments are necessary to determine therapeutic efficacy and to make necessary adjustments to therapy.