Sulfamethoxazole and Trimethoprim Injection Multiple-Dose Vial 30 mL (RX)
(Note: We don’t Fill Personal Prescriptions)
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Sulfamethoxazole and Trimethoprim Injection in a 30 mL multiple-dose vial is a powerful antibiotic formulation used for the treatment of various bacterial infections. This combination drug includes two active ingredients: sulfamethoxazole, a sulfonamide antibiotic, and trimethoprim, which work synergistically to inhibit bacterial growth. This injectable form is particularly useful in clinical settings for patients who are unable to take oral medications, ensuring reliable delivery of the medication directly into the bloodstream for faster therapeutic effect.
Perfect for hospital and healthcare environments, this injectable solution is highly effective in addressing infections such as urinary tract infections, respiratory infections, and specific gastrointestinal infections, among others. As always, administration of this medication should be undertaken by healthcare professionals with appropriate medical supervision.
Product Details:
Active Ingredients: Sulfamethoxazole and Trimethoprim
Formulation: Injectable solution in a multiple-dose vial
Volume: 30 mL
Indications: Treatment of susceptible bacterial infections including urinary tract infections, respiratory tract infections, gastrointestinal infections, and certain types of shigellosis and pneumonia.
Mechanism of Action:
The combination of sulfamethoxazole and trimethoprim works by sequentially inhibiting enzymes in the bacterial folic acid synthesis pathway. Sulfamethoxazole inhibits dihydropteroate synthase, and trimethoprim inhibits dihydrofolate reductase. This dual blockade results in effective suppression of bacterial growth by preventing the formation of tetrahydrofolate, which is crucial for the synthesis of DNA, RNA, and proteins in bacteria.
Warnings:
- Hypersensitivity: Contraindicated in patients with known allergies to sulfonamides or trimethoprim.
- Pregnancy and Lactation: Use with caution during pregnancy and breastfeeding.
- Discuss potential risks with a healthcare professional.
- Renal or Hepatic Impairment: Adjust dosing and monitor closely in patients with kidney or liver dysfunction.
- Blood Disorders: Monitor for signs of blood dyscrasias such as agranulocytosis, aplastic anemia, or thrombocytopenia.
Side Effects:
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Common: Nausea, vomiting, diarrhea, and rash.
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Serious: Stevens-Johnson syndrome, toxic epidermal necrolysis, hepatic necrosis, agranulocytosis, anemia, and severe hypersensitivity reactions.
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Renal: Crystalluria and interstitial nephritis, particularly in dehydrated patients.
- Hematologic: Leukopenia, thrombocytopenia, and megaloblastic anemia especially in individuals with pre-existing folate deficiency.
Consultation Recommendations:
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Administration: Intravenous infusion should be administered by a healthcare professional.
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Hydration: Ensure sufficient fluid intake to prevent crystalluria and renal complications.
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Monitor: Regularly monitor blood counts, renal function, and liver function tests in patients receiving prolonged therapy.
- Drug Interactions: Inform your healthcare provider about all medications and supplements being taken to evaluate potential interactions.
Sulfamethoxazole and Trimethoprim Injection provides targeted and effective therapy against a range of bacterial infections, leveraging a well-established antibiotic combination trusted in clinical practice. Always ensure dosages conform to medical guidelines and patient-specific conditions for optimal results and safety.