Amphotericin B for Injection 50 mg Vial For Intravenous Infusion Only **Refrigerated Product (RX)

Amphotericin B for Injection 50 mg is an antifungal medication used to treat serious fungal infections. It targets severe systemic infections by binding to fungal cell membranes, causing cell death. This effective treatment is often employed for life-threatening conditions like aspergillosis, candidiasis, and mucormycosis. Amphotericin B is administered intravenously in a clinical setting, due to its potential for significant side effects and the necessity for careful monitoring by healthcare professionals.

Introducing Amphotericin B for Injection, a premier antifungal medication offered by Xgen Pharma, designed to provide effective treatment against severe fungal infections. With a longstanding reputation for its potent antifungal properties, Amphotericin B remains a critical choice in the management of systemic mycoses and a cornerstone for healthcare professionals worldwide.

Product Details and Features

Product Name: Amphotericin B for Injection
Strength: 50 mg per vial
Manufacturer: Xgen Pharma
Dosage Form: Lyophilized powder for intravenous use
Packaging: Available in a sterile vial for reconstitution
Indications: Indicated for the treatment of systemic fungal infections such as cryptococcal meningitis, aspergillosis, candidiasis, histoplasmosis, and leishmaniasis, among others.
Storage Conditions: Store at temperatures between 2°C to 8°C (36°F to 46°F) and protect from light.

Features

• Broad-spectrum Efficacy: Effective against a wide range of pathogenic yeasts and molds.
  
• Gold Standard Antifungal: Considered the treatment of choice for life-threatening systemic fungal infections.
  
• Proven Track Record: Well-established with decades of clinical use and research.
  
• Expert Manufacture: Produced with precision by Xgen Pharma, guaranteeing quality and reliability.

Mechanism of Action

Amphotericin B targets fungal cell membranes. It binds to ergosterol, a vital component of fungal cell membranes, thereby creating pores in the cell membrane. This leads to increased membrane permeability, allowing essential ions like potassium and other molecules to leak out. The resultant loss of cellular contents causes cell death, making Amphotericin B a powerful fungicidal agent against a variety of fungi.

Directions for Use

1. Reconstitution: To reconstitute, aseptically add 10 mL of Sterile Water for Injection to the vial containing 50 mg of Amphotericin B, resulting in a concentration of 5 mg/mL. Gently shake to ensure complete dissolution.
2. Dilution: Further dilute the reconstituted solution in 500 mL of 5% Dextrose Injection to attain a concentration in the range of 0.1 mg/mL to 0.25 mg/mL before administration.
3. Administration: Administer intravenously over a period of 2 to 6 hours. The rate of infusion may be adjusted according to patient tolerance.
4. Dosage: The specific requirements for dosage will depend on the type, severity of infection, and patient’s condition. Initiate treatment under the supervision of a qualified healthcare professional.

Warnings

• Renal Impairment: Use with caution in patients with preexisting renal damage or impairment. Regular monitoring of renal function is advised.
  
• Infusion Reactions: Patients may experience acute infusion-related reactions such as fever, chills, or headache. Pre-treat with antipyretics or antihistamines if necessary.
  
• Monitor Electrolytes: Potential for hypokalemia and hypomagnesemia. Monitor and adjust electrolyte levels as needed.
  
• Drug Interactions: May interact with other nephrotoxic agents or medications affecting electrolyte balance.

Side Effects

The use of Amphotericin B can lead to side effects in some patients. Notable potential side effects include:

• Infusion-related Symptoms: Fever, chills, nausea, vomiting, and muscle or joint pain.
  
• Nephrotoxicity: Renal impairment may occur, leading to increased blood urea and creatinine levels.
  
• Electrolyte Imbalance: Hypokalemia (low potassium levels) and hypomagnesemia (low magnesium levels).
  
• Anemia: Occasional reports of anemia with prolonged usage.
  
• Hepatic Dysfunction: Possible liver enzyme elevation. 

Always discuss with a healthcare professional before starting any new medication. Adherence to recommended treatment guidelines and continuous monitoring will help mitigate potential risks.

For comprehensive treatment consideration, trust Amphotericin B for Injection by Xgen Pharma – your definitive choice for combating serious fungal infections.