Solu-Medrol 125 mg Injection 2 ml Vials, 25/Pack (RX)

Solu-Medrol 125 mg Injection is a corticosteroid medication used to rapidly reduce inflammation and suppress the immune response in various acute conditions, including severe allergic reactions, asthma attacks, and flare-ups of chronic illnesses like rheumatoid arthritis and lupus. Administered intravenously or intramuscularly, it provides quick relief from symptoms such as swelling, redness, and itching, while managing severe conditions that require immediate intervention.

Benefits for Solu-Medrol for Injection 2 ml Vials, 125 mg

Rapid onset of symptom relief from conditions related to inflammation, such as pain, swelling, and allergic reactions
Cost-effective and prolonged symptom relief
Can be administered as an IV push or slowly over longer periods of time
Fewer side effects than oral formulations and other corticosteroids
Can be tailored to the individual's needs in terms of dose and delivery
Used to treat a wide range of conditions, including asthma, seasonal allergies, rheumatoid arthritis, lupus, multiple sclerosis, and certain types of cancer
Can be used to reduce124 mg of inflammation in one dose
Offers improved safety as a centrally acting steroid, minimizing the systemic absorption of the drug
No need to premedicate for hypersensitivity with Solu-Medrol
Short half-life and rapid clearance, reducing the risk of long-term side effects

Solu-Medrol (Methylprednisolone Sodium Succinate) is a corticosteroid used to treat conditions involving inflammation and immune response, such as severe allergic reactions, arthritis, lupus, multiple sclerosis, and certain endocrine disorders. This formulation is designed for intravenous or intramuscular administration, utilizing rapid absorption to ensure a swift therapeutic response in acute situations.

Details and Features

Active Ingredient: Methylprednisolone Sodium Succinate
Concentration: 125 mg per 2 mL vial
Formulation: Powder for injection that must be reconstituted before use
Packaging: Available in multiple-use packs, typically containing 25 vials
Manufacturer: Pfizer Injectables
Usage: Primarily used for quick intervention in severe inflammation and immune-mediated conditions, in both inpatient and outpatient settings.
NDC: 00009-0047-22
UPC: 300090047221

Mechanism of Action

Methylprednisolone, the active ingredient in Solu-Medrol, exerts its effects by inhibiting multiple inflammatory pathways. It blocks the expression of inflammatory mediators such as cytokines and chemokines, reducing their ability to promote inflammation and immune response. The drug alters gene transcription, leading to decreased production of substances that promote inflammation and increased production of anti-inflammatory proteins.

Warnings

• Increased Susceptibility to Infections: Can suppress the body’s immune response, increasing the risk of infections and masking existing infection symptoms.
  
• Endocrine Effects: Prolonged use can lead to adrenal suppression, Cushing's syndrome, and hypothalamic-pituitary-adrenal (HPA) axis suppression.
  
• Cardiovascular: May cause hypertension, fluid retention, and electrolyte imbalances.
  
• Gastrointestinal Risks: Potential for peptic ulcers, GI bleeding, or perforation in susceptible individuals.
  
• Bone Density: Long-term use can result in bone loss or osteoporosis.
  
• Psychiatric Effects: Possible mood swings, depression, or other psychiatric symptoms.
  
• Ophthalmic Concerns: Risk of cataracts, glaucoma, and exacerbation of eye infections.

Side Effects

Common Side Effects:

- Insomnia
- Increased appetite and weight gain
- Mood changes or irritability
- Edema (fluid retention)

Serious Side Effects:

• Peptic ulcers and gastrointestinal bleeding
• Osteoporosis with possible fracture risk in long-term use
• Elevated blood sugar levels, problematic in diabetic patients
• Severe infections due to immunosuppression
• Hypertension and cardiovascular complications

Administration and Monitoring

Solu-Medrol should be administered by healthcare professionals familiar with corticosteroid therapy. Close monitoring is necessary to manage dosages and mitigate potential complications, especially during prolonged treatment courses. Monitoring might include periodic evaluation of blood pressure, blood sugar levels, and bone density. Adjustments in therapy should be guided by clinical response and the patient's condition, considering the lowest dosage for therapeutic efficacy to minimize side effects.