Hylenex Injection Recombinant Hyaluronidase Human Injection 1 mL, 150 Units/mL (Rx) *Refrigeration Item*

Hylenex Injection is used to enhance the dispersion and absorption of subcutaneously injected medications. It contains hyaluronidase, an enzyme that modifies the permeability of connective tissues by hydrolyzing hyaluronic acid, a component of the extracellular matrix. Hylenex is commonly used to facilitate subcutaneous fluid administration, enhance the delivery of anesthetics, and increase the efficacy of rehydration. It is also helpful in improving the uptake of contrast agents in imaging procedures and accelerating the absorption of injected drugs.

Note: Refrigerated Item, Ships Next Day Air, Signature Required

Hylenex is a formulation of recombinant human hyaluronidase used to enhance the absorption and dispersion of other injected drugs. Primarily employed in subcutaneous fluid administration, Hylenex facilitates accelerated drug delivery for rehydration, contrast agent dispersion, or anesthesia. By breaking down hyaluronic acid, it temporarily increases tissue permeability, allowing for efficient drug and fluid dispersion. This can improve the effectiveness of subcutaneous injections and is a valuable tool in emergency medicine and certain medical procedures.

Details and Features:

Formulation: Hylenex is supplied as a clear, colorless, sterile liquid solution in a 1 mL vial containing 150 units/mL of recombinant human hyaluronidase.
Administration: Typically administered subcutaneously as part of other therapies to enhance drug absorption.
Storage: Hylenex should be stored refrigerated at 2-8°C (36-46°F).

Mechanism of Action:

Hylenex works by temporarily breaking down hyaluronic acid, a component of the extracellular matrix in tissues. Hyaluronic acid forms a barrier to the diffusion of fluids, so by decreasing its viscosity, Hylenex enhances the permeability of subcutaneous or connective tissue. This action enables faster absorption and spread of co-administered drugs or fluids injected under the skin.

Side Effects:

Potential side effects of Hylenex may include:

• Local injection site reactions (redness, swelling, itching)
  
• Mild discomfort or irritation at the injection site
  
• Rare systemic allergic reactions

Warnings:

• Hypersensitivity: Should not be used in individuals with a known allergy to hyaluronidase or any of the formulation's components.
  
• Not for Direct Injection into Veins or Eyes: The enzyme is not designed for intravenous or intraocular use.
  
• Pregnancy and Nursing: Consult with a healthcare provider, as the effects during pregnancy or breastfeeding are not fully established.
  
• Drug Interactions: Potential interactions with other medications must be reviewed by healthcare professionals.
  Infection risk: Areas of infection or inflammation should be approached cautiously, as the enzyme may facilitate the spread of infection.

Usage Considerations:

Patients should inform their healthcare providers of any allergies, medical conditions, or current medications to ensure safety and efficacy, and they should be closely monitored following administration for any adverse effects.