Meropenem for Injection 500 mg Vials 10-Pack by Amneal (Rx)

Meropenem for Injection 500 mg is a broad-spectrum antibiotic used to treat severe bacterial infections, including those of the skin, abdominal cavity, and central nervous system, such as meningitis. It belongs to the carbapenem class of antibiotics, which work by inhibiting bacterial cell wall synthesis, leading to cell death. Meropenem is especially effective against multi-drug-resistant infections and is administered intravenously in hospital settings. It is critical for managing life-threatening infections and is reserved for cases where other antibiotics may not be effective.

Meropenem for Injection, provided by Amneal Pharmaceuticals, is a broad-spectrum antibiotic belonging to the carbapenem class. It is used to treat severe or complicated bacterial infections and is particularly effective against a wide array of Gram-positive and Gram-negative bacteria, as well as anaerobic pathogens. This product is packaged in 500 mg vials, with each pack containing 10 vials, intended for intravenous administration.

Details and Features

Active Ingredient: Meropenem
Strength: 500 mg per vial
Formulation: Powder for reconstitution into an injectable solution
Packaging: 10 vials per pack
Route of Administration: Intravenous (IV) infusion
Indications: Used for the treatment of complicated intra-abdominal infections, bacterial meningitis, and complicated skin and skin structure infections, among other serious bacterial infections.

Mechanism of Action

Meropenem exerts its antibacterial effects by inhibiting bacterial cell wall synthesis. It achieves this by binding to penicillin-binding proteins (PBPs), which hinders the formation of the bacterial cell wall. As a result, the integrity of the bacterial cell wall is compromised, leading to cell lysis and death. This mechanism is effective against a broad spectrum of bacteria, including difficult-to-treat strains.

Warnings

• Hypersensitivity Reactions: Patients with a history of hypersensitivity to carbapenems, beta-lactams, or any component of the formulation may face severe allergic reactions, including anaphylaxis.
  
• CNS Effects: Use with caution in patients with central nervous system disorders such as epilepsy; meropenem may lower the seizure threshold.
  
• Superinfection Risk: Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi.
  
• Renal Impairment: Dose adjustments may be necessary in patients with renal dysfunction to prevent accumulation and toxicity.
  
• Cross-Sensitivity: Cross-reactivity may occur in patients with a history of penicillin allergy, although it is relatively rare.

Side Effects

Common and serious side effects may occur during meropenem administration:

Common Side Effects:

• Nausea
• Vomiting
  
• Diarrhea
  
• Headache
  
• Rash or injection site reactions

Serious Side Effects:

• Severe allergic reactions such as anaphylaxis
  
• Seizures, particularly in patients with renal impairment or CNS disorders
  
• Clostridium difficile-associated diarrhea, due to disruption of normal gut flora
  
• Hematologic effects such as thrombocytopenia or neutropenia

Meropenem for Injection must be administered under the supervision of healthcare professionals with appropriate monitoring for adverse effects. The therapeutic regimen should be tailored based on the severity of infection, the susceptibility of the microorganisms involved, and the patient's clinical status. Adjustments in dosing, particularly in special populations with renal impairment, are crucial to optimize treatment outcomes and minimize risks.