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Naloxone Injection 0.4 mg Vials, Single-Dose 10/Box by Pfizer (RX)

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Original price $ 450.00
Current price $ 395.00
SKU 00409-1215-01
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(Note: We don’t Fill Personal Prescriptions)


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Naloxone Injection 0.4 mg Vials are used as an emergency treatment to rapidly reverse the effects of opioid overdose, including life-threatening symptoms such as respiratory depression, sedation, and loss of consciousness. Naloxone is an opioid antagonist that works by displacing opioids from their receptors in the brain, quickly restoring normal breathing and consciousness. It is vital in emergency medical situations and is administered by healthcare professionals or trained individuals until further medical care is available.

Naloxone Injection is an opioid antagonist used to rapidly reverse the effects of opioid overdose, such as respiratory depression, sedation, and hypotension. It is an emergency treatment that restores normal respiration in individuals who have overdosed on opioids including heroin, morphine, and prescription opioid medications. This product is provided by Pfizer Injectables and comes in single-dose glass vials, each containing 0.4 mg of naloxone, packaged in boxes of 10 vials for clinical or emergency use.

Details and Features

Active Ingredient: Naloxone Hydrochloride
Concentration: 0.4 mg per vial
Packaging: Single-dose glass vials, 10 vials per box
Formulation: Sterile solution for injection
Administration: Can be administered intravenously, intramuscularly, or subcutaneously
Purpose: Emergency treatment of opioid overdose; restores breathing and reverses sedation
Manufacturer: Pfizer Injectables

Mechanism of Action

Naloxone is an opioid antagonist that works by competitively binding to opioid receptors in the central nervous system. By displacing opioids from these receptors, naloxone blocks their effects, especially the potentially fatal respiratory depression. This results in the rapid recovery of consciousness and breathing in individuals experiencing opioid overdose. Its action is quick but may require repeated doses due to its shorter duration compared to many opioids.

Warnings

  • Recurrent Respiratory Depression: Since naloxone's duration of action is shorter than that of some opioids, repeated doses may be necessary if symptoms reoccur.
  • Precipitation of Withdrawal: In opioid-dependent individuals, naloxone may cause acute withdrawal symptoms, which can include agitation, nausea, vomiting, and sweating.
  • Cardiovascular Effects: Use with caution in patients with cardiovascular disease or those receiving medications with potential cardiovascular effects.
  • Must Be Administered by Trained Personnel: Ideally administered by healthcare providers trained to recognize and manage opioid overdoses, although it may also be administered by trained first responders or laypersons in community settings.

Side Effects

Common Side Effects:

  • Sweating
  • Nausea or vomiting
  • Shakiness or tremors

Serious Side Effects:

  • Acute opioid withdrawal symptoms in opioid-dependent individuals
  • Cardiovascular complications, especially in those with pre-existing conditions or when administered rapidly

Administration and Monitoring

Naloxone should be administered by trained individuals who can recognize the signs of opioid overdose and determine the appropriate use of the medication. It can be given via intravenous, intramuscular, or subcutaneous routes, depending on the scenario and available resources. Patients require continuous monitoring after administration due to the potential recurrence of overdose symptoms when naloxone's effects wear off. In emergency medical settings, preparation for managing withdrawal symptoms or potential complications should be in place, including additional doses of naloxone or other supportive measures as required.

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