Ondansetron 8 mg Orally Disintegrating Tablets by Glemark (RX)

Ondansetron is a medication primarily used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. Ondansetron is an antiemetic that works by blocking the actions of chemicals in the body that can trigger nausea and vomiting.

Dosage Form:

• Orally Disintegrating Tablets
• Strength: 8 mg
• Supplied by Glenmark Pharmaceuticals

Mechanism of Action:

Ondansetron is a selective 5-HT3 receptor antagonist, which blocks serotonin, a natural substance in the body that causes vomiting.

Indications:

• Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
• Prevention of nausea and vomiting associated with radiotherapy.
• Prevention of postoperative nausea and/or vomiting.

Administration:

The tablet should be placed on the tongue and allowed to dissolve, then swallowed with saliva. The tablet dissolves quickly in the mouth, specifically formulated for patients who have difficulty swallowing.

Packaging: Available in a blister pack, ensuring each tablet is individually sealed to maintain its integrity and potency.

Other Information:

• Inactive Ingredients: May include mannitol, aspartame, and other excipients that aid in the disintegration of the tablet.
• Storage: Store at room temperature, away from moisture and heat.

Precautions:

• Patients with liver problems, electrolyte imbalances, or a history of heart conditions should inform their healthcare provider before starting Ondansetron.
• Possible side effects include headache, dizziness, drowsiness, and constipation.
    
  Note: Always follow the prescribing doctor's guidelines and instructions for this medication to ensure its effectiveness and safety.

Ondansetron 8 mg tablets belong to a class of medications known as selective serotonin 5-HT3 receptor antagonists. They work by blocking the action of serotonin, a neurotransmitter in the brain that is responsible for triggering feelings of nausea.

Specifically, ondansetron binds to and blocks the 5-HT3 receptors in the digestive system and the brain, preventing serotonin from binding to these receptors. This results in a decrease in the activity of the vomiting center in the brain and a decrease in the signals sent to the digestive system, reducing the sensation of nausea and preventing vomiting.

In addition to its action on the 5-HT3 receptors, ondansetron may also act on other receptors in the brain and gut, such as dopamine, GABA, and opioid receptors, to further reduce nausea and vomiting.

Overall, the mechanism of action for ondansetron 8 mg tablets is to inhibit the activity of serotonin and other neurotransmitters in the body that are involved in initiating the vomiting reflex. This makes it an effective medication for managing nausea and vomiting associated with a variety of conditions, including chemotherapy, radiation therapy, and post-operative nausea.