Itraconazole Capsules 100 mg by Ascend Laboratories 30 Count (Rx)

Itraconazole is an oral antifungal medication used to treat a variety of fungal infections. It is commonly prescribed for infections such as aspergillosis, histoplasmosis, and onychomycosis (fungal infections of the nails). Itraconazole works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, thereby disrupting cellular integrity and growth. It is crucial to follow the healthcare provider's dosage and administration guidelines to ensure effectiveness and minimize potential side effects and drug interactions.

Itraconazole Capsules 100 mg by Ascend Laboratories offer a high-quality antifungal solution, crafted to effectively tackle a variety of fungal infections. Known for its broad-spectrum activity, itraconazole is frequently prescribed for conditions such as histoplasmosis, blastomycosis, and fungal nail infections. With Ascend Laboratories' commitment to ensuring the highest standards of safety and efficacy, these capsules provide a reliable option for both healthcare providers and patients seeking effective fungal infection management.

Details and Features:

Active Ingredient: Each capsule contains 100 mg of itraconazole, recognized for its potent antifungal properties and effectiveness against both dermatophytes and systemic fungal infections.  
Count: Packaged in a bottle containing 30 capsules, offering a sufficient supply for typical treatment courses as prescribed by a healthcare provider.  
Broad-Spectrum Antifungal: Effective against a wide range of fungal pathogens, making it suitable for treating various systemic and localized infections.  
Targeted Therapy: Often the treatment of choice for infections in patients with compromised immune systems, including those suffering from chronic fungal conditions.  
Quality Assurance: Manufactured under rigorously controlled conditions to ensure potency, safety, and reliability, in line with healthcare regulations.  

Mechanism of Action:

Itraconazole, an azole antifungal, exerts its fungicidal action by inhibiting the cytochrome P450-dependent enzyme 14α-demethylase. This enzyme is essential for converting lanosterol into ergosterol, an integral component of fungal cell membranes. By disrupting ergosterol synthesis, itraconazole compromises the cell membrane structure, impairing fungals' survival and proliferation capabilities, resulting in cellular death and resolution of infection.

Directions:

1. Dosage: Strictly follow your healthcare provider's prescribed dosage, typically involving a 200 mg (two capsules) daily dose, which may adjust based on the specific infection being treated.  
2. Administration: Take with a full meal to enhance absorption and ensure more effective systemic distribution.  
3. Consistency: For optimal results, take at the same time each day to maintain consistent levels in the bloodstream.  
4. Duration: Complete the full treatment course even if symptoms improve earlier to adequately resolve the infection and prevent fungal resistance.  
5. Capsule Integrity: Swallow the capsule whole; do not crush or chew to preserve the integrity and release mechanism of the medication.  

Warnings:

• Liver and Heart Concerns: Use with caution in patients with liver or heart conditions. Liver function should be monitored periodically to detect any potential drug-induced hepatotoxicity.  
  
• Drug Interactions: Itraconazole can interact with various medications, including some cholesterol drugs, antihistamines, and antiarrhythmics. It's essential to inform your healthcare provider of all medications being taken.  
  
• Pregnancy and Nursing: Should not be used during pregnancy unless deemed necessary by a healthcare provider due to potential fetal harm. Use during breastfeeding is not recommended without consulting a physician.  
  
• Specific Patient Risk: Those with a history of cardiac dysfunction, particularly heart failure, should utilize alternative therapies or closely monitor impacts due to itraconazole's potential exacerbation of these conditions.  

Side Effects:

Common side effects might include nausea, dizziness, headache, stomach pain, and mild changes in liver enzymes. These are mostly manageable and may resolve as therapy continues. However, serious side effects such as signs of heart issues (e.g., leg swelling, unusual weight gain), liver problems (e.g., persistent nausea, unusual tiredness, dark urine, jaundice), or signs of allergic reactions require immediate medical attention.

With Itraconazole Capsules 100 mg by Ascend Laboratories, patients receive an effective, well-established antifungal treatment tailored to combating stubborn infections with precision and reliability. As always, ensure regular consultations with your healthcare professional to personalize and safely manage your treatment journey, minimizing potential risks while maximizing therapeutic outcomes.