Naloxone Hydrochloride Injection 0.4 mg Multiple-dose 10 mL Flip-top Vials, 25/Tray

Naloxone Hydrochloride Injection 0.4 mg vials are used for the rapid reversal of opioid overdose effects. By blocking opioid receptors in the brain, naloxone quickly restores normal breathing and consciousness in individuals experiencing an overdose. It is an essential emergency tool to counteract life-threatening respiratory depression and is used by healthcare professionals and emergency responders. Although naloxone acts swiftly, it is a temporary measure, and the individual requires immediate medical attention afterward to ensure proper care and supervision.

Experience immediate and effective intervention in opioid overdose cases with Pfizer Injectables' Naloxone Hydrochloride Injection. This versatile opioid antagonist is delivered in a 0.4 mg/mL concentration within multiple-dose 10 mL flip-top vials, enabling healthcare professionals to administer life-saving treatment swiftly and efficiently. Packaged in trays of 25, these vials are designed for use in high-demand environments such as hospitals, emergency departments, and clinics, where rapid response is paramount in reversing opioid toxicity.

Product Details and Features:

Active Ingredient: Each 10 mL vial contains a concentration of 0.4 mg/mL Naloxone Hydrochloride, specifically formulated for managing and reversing the effects of opioids.
Packaging: The multiple-dose vials come with flip-top caps, promoting ease of access while maintaining sterility, and are held in trays of 25 to meet the needs of busy medical facilities.
Indications: Primarily indicated for the complete or partial reversal of opioid effects, particularly respiratory depression, sedation, and hypotension, associated with both natural and synthetic opioids.
Versatility: Useful in a variety of clinical settings, from emergency interventions in the ER to supportive care in post-operative recovery units, providing flexibility and reliability.
Pharmaceutical Excellence: Manufactured by Pfizer, known for its adherence to stringent quality standards, ensuring efficacy and safety in every vial.

Mechanism of Action:

Naloxone Hydrochloride operates by competitively binding to opioid receptors in the central nervous system. By displacing opioids at these receptor sites, it effectively reverses the life-threatening effects, such as respiratory depression and sedation, without activating the receptors. This mechanism quickly restores normal respiratory function, counteracting overdoses of both prescription and illicit opioids.

Warnings:

• Opioid Withdrawal: In patients dependent on opioids, rapid administration may precipitate acute withdrawal symptoms. Monitor patients closely and titrate dosages carefully.
  
• Cardiovascular Considerations: Use with caution in patients with pre-existing cardiovascular conditions. Rapid reversal may induce stress on the heart and require careful monitoring.
  
• Duration of Action: The effects of naloxone are generally shorter than those of many opioids, potentially necessitating repeated doses or continuous monitoring to prevent resedation.
  
• Hypersensitivity: Do not administer to individuals with known hypersensitivity to naloxone hydrochloride or any of the excipients.

Side Effects:

Common side effects may include:

• Nausea and vomiting
  
• Sweating
  
• Elevated blood pressure
  
• Tachycardia

Serious reactions require immediate medical attention:

• Severe withdrawal symptoms in opioid-dependent patients, including agitation, anxiety, or seizures
  
• Cardiovascular symptoms, especially in patients with a history of heart disease or arrhythmias

Conclusion:

Naloxone Hydrochloride Injection in its multiple-dose, 10 mL flip-top vials by Pfizer Injectables is an indispensable component of emergency medical care against opioid overdose. With its swift and dependable action, it provides a critical tool for healthcare providers aiming to enhance patient outcomes in opioid toxicity scenarios. Embrace the reliable quality and innovative design that Pfizer offers, ensuring preparedness in urgent medical situations.