Naloxone Hydrochloride Injection 0.4 mg Prefilled Syringes Carpuject Cartridge with Luer Lock, 10/Box

Naloxone Hydrochloride Injection 0.4 mg Prefilled Syringes are used for the emergency treatment of opioid overdoses. Naloxone rapidly reverses the effects of opioids, such as respiratory depression, sedation, and loss of consciousness, by displacing opioids from their receptors in the brain. It is a critical intervention in preventing fatal overdose outcomes. Medical personnel, as well as trained laypersons, commonly use these prefilled syringes due to their ease of administration. Naloxone acts quickly, but emergency medical attention is still required after administration, as it is a temporary solution.

Pfizer Injectables presents Naloxone Hydrochloride Injection, a life-saving medication designed for rapid intervention in cases of opioid overdose. Offered in convenient 0.4 mg prefilled syringes within the Carpuject Cartridge system with Luer Lock, this product is engineered for precision and efficiency, ensuring swift action in critical situations. Boxed in sets of 10, it is an essential tool for emergency responders and healthcare providers, delivering an opioid antagonist with reliability and ease of use.

Product Details and Features:

Active Ingredient: Each prefilled syringe contains 0.4 mg of Naloxone Hydrochloride, a potent opioid antagonist used to counteract the life-threatening effects of opioid overdose.
Carpuject Cartridge System: The prefilled syringes are part of the Carpuject Cartridge system, equipped with a Luer Lock to ensure secure and straightforward administration in high-pressure scenarios.
Packaging: Available in boxes of 10 syringes, prepared for quick accessibility to support emergency interventions.
Indications: Specifically designed for rapid reversal of opioid effects, including respiratory depression, sedation, and hypotension. Suitable for use in both pre-hospital and in-hospital settings.
Reliability: Manufactured by Pfizer, a leader in pharmaceutical solutions, ensuring the highest standards of safety, quality, and effectiveness in acute care.

Mechanism of Action:

Naloxone Hydrochloride functions as an opioid receptor antagonist. It binds to opioid receptors in the central nervous system, displacing opioids and reversing their effects, particularly the dangerous respiratory depression associated with overdose. This alleviates symptoms and restores normal respiratory function without producing significant agonist effects, ensuring safety across different patient populations.

Warnings:

• Opioid Dependency: Excessive unusual doses in opioid-dependent patients may precipitate acute withdrawal symptoms. Administration requires monitoring and careful titration.
  
• Cardiovascular Concerns: Use cautiously in patients with pre-existing heart conditions or electrolyte imbalances, as abrupt reversal may induce cardiac stress.
  
• Short Duration of Action: The effects of naloxone may be shorter than the opioids, necessitating repeated dosing or continuous monitoring to manage resedation.
  
• Hypersensitivity: Do not use in patients with known hypersensitivity to naloxone or any formulation components.

Side Effects:

Common side effects may include:

• Nausea and vomiting
  
• Diaphoresis
  
• Increased blood pressure and tachycardia

Serious side effects or situations necessitating immediate attention:

• Signs of acute opioid withdrawal in dependent individuals, including agitation, tremors, or convulsions.
  
• Severe cardiovascular symptoms, notably in those with a history of heart disease or irregular heartbeat.

Conclusion:

Naloxone Hydrochloride Injection by Pfizer Injectables is a critical resource for combating opioid overdose, offering rapid antagonistic action through a reliable and user-friendly delivery system. With its precise dosing and trusted Pfizer quality, it stands as a crucial part of emergency medical care, empowering first responders and healthcare providers to save lives and mitigate the rising risks of opioid toxicity.