Depo-Medrol Injection Methylprednisolone 100 mg/5 mL (20 mg/mL) Multiple Dose Vials 5 mL (Rx)

Depo-Medrol Injection Methylprednisolone is a corticosteroid medication used to reduce inflammation and manage symptoms in various conditions, such as allergies, arthritis, lupus, and skin disorders. It is administered via injection to deliver targeted relief from pain and swelling. This medication helps modulate immune response and provides medication with longer-lasting effects in controlling severe or persistent inflammatory conditions.

Depo-Medrol Injection is a corticosteroid medication containing Methylprednisolone Acetate. It is used to manage a variety of inflammatory and autoimmune conditions, as well as to treat severe allergies and certain systemic conditions. Provided by Pfizer Injectables, this formulation is typically used by healthcare professionals in clinical settings.

Details and Features:

Active Ingredient: Methylprednisolone Acetate
Concentration: 100 mg per 5 mL (20 mg/mL) 
Volume: 5 mL per vial
Formulation: Suspension for injection (multiple dose vial)
Packaging: Multiple-dose vials
Manufacturer: Pfizer Injectables
Indications: Used in the management of conditions like rheumatoid arthritis, lupus, allergic reactions, severe asthma, inflammatory bowel disease, and other inflammatory conditions.
NDC: 00009-0274-01
UPC: 300090274016

Mechanism of Action

Methylprednisolone is a corticosteroid that suppresses inflammation and the immune response. It works by inhibiting the release of substances in the body that lead to inflammation, such as prostaglandins and leukotrienes. Its immunosuppressive effects are due to the reduction in the proliferation of immune cells and modulation of the transcription of inflammatory cytokines.

Warnings

• Infections: Increased risk of infection (masked symptoms)
  
• Vaccinations: Avoid live vaccines; diminished response to inactivated vaccines
  
• Endocrine Effects: Risk of adrenal suppression and Cushing’s syndrome with prolonged use 
  
• Gastrointestinal Risks: Use with caution in patients with peptic ulcer disease or other gastrointestinal disorders
  
• Cardiovascular Risks: May lead to elevated blood pressure or worsening of existing cardiac conditions
  
• Pregnancy and Lactation: Use is generally evaluated based on risk versus benefit during pregnancy or while breastfeeding.

Side Effects

Common Side Effects:

• Increased appetite or weight gain
  
• Insomnia
  
• Mood swings or irritability
  
• Fluid retention and swelling

Serious Side Effects:

• Peptic ulcers or gastrointestinal bleeding
  
• Psychological effects: Depression, euphoria, or other mood disorders
  
• Increased risk of infections
  
• Osteoporosis or decreased bone density with long-term use
  
• Hyperglycemia, particularly concerning for diabetic patients

Administration and Monitoring

Depo-Medrol should only be administered by qualified healthcare practitioners familiar with steroid injections and the potential systemic effects. Regular monitoring of blood pressure, blood sugar levels, and signs of infection are recommended during extended therapy. Patients on long-term therapy may require periodic evaluation for bone density, and adjustment in dosage might be necessary based on clinical response and side effects. Always consult detailed prescribing information for comprehensive guidelines and contraindications.