Diltiazem Hydrochloride 100 mg Injection Single-dose ADD-Vantage Vials 10/Box (RX)

Diltiazem Hydrochloride 100 mg Injection is a calcium channel blocker used to manage acute episodes of certain types of arrhythmias, such as atrial fibrillation or atrial flutter, and to control high blood pressure and chest pain (angina). It works by relaxing the blood vessels and reducing heart rate, improving blood flow, and decreasing cardiac workload. This medication is typically administered intravenously in a clinical setting for rapid control of these cardiovascular conditions.

Benefits for Diltiazem Hydrochloride for Injection:

• Rapid onset of action: Diltiazem Hydrochloride for Injection Single-dose ADD-Vantage Vials provide a rapid onset of action, which means that it can offer prompt relief from symptoms of angina, hypertension, and arrhythmia.
• Improved patient compliance: The single-dose, disposable vials make it easier for patients to take their medication with them when needed, reducing the risk of noncompliance.
• Cost-effective: The single dose vials allow for more economical use of medication since they can be used for multiple treatments per vial.
• Precise dosing: The single-dose vials ensure that the right amount of medication is administered each time, helping to enhance the patient’s healthcare outcomes.
• Reduced risk of infection: The single-dose vials help to reduce the risk of contamination or cross-contamination of medication compared to using multiple dose bottles.
• Avoid waste: Since single-dose vials contain only the precise amount of medication, there is virtually no risk of waste or disposal of unused medication.

Details and Features

- Active Ingredient: Diltiazem Hydrochloride
- Strength: 100 mg per vial
- Packaging: 10 single-dose ADD-Vantage vials per box
- Formulation: Sterile solution for injection after reconstitution
- Administration: Intended for intravenous use
- Manufacturer: Pfizer Injectables
- Purpose: Used to manage cardiac arrhythmias, hypertension, and angina

Mechanism of Action

Diltiazem is a calcium channel blocker that acts by inhibiting the influx of calcium ions across cardiac and vascular smooth muscle cell membranes during depolarization. This action decreases myocardial contractility and conduction velocity in the heart, as well as dilates the coronary and peripheral arteries. As a result, diltiazem lowers heart rate, reduces myocardial oxygen demand, and decreases blood pressure, which helps control heart rhythm and alleviate angina.

Warnings

• Cardiac Warnings: Use is contraindicated in patients with severe hypotension, cardiogenic shock, sick sinus syndrome, or second- or third-degree AV block without a pacemaker.
  
• Heart Failure: Use with caution in patients with congestive heart failure, as diltiazem may exacerbate symptoms.
  
• Hepatic and Renal Impairment: Dosage adjustments and careful monitoring may be needed for patients with liver or kidney dysfunction.
  
• Drug Interactions: Caution when used concurrently with other medications that affect cardiac function or blood pressure, such as beta-blockers or digoxin, as additive effects may occur.

Side Effects

Common Side Effects:

• Bradycardia
  
• Dizziness or light-headedness
  
• Flushing
  
• Headache

Serious Side Effects:

• Severe hypotension
  
• Heart block or worsening arrhythmias
  
• Congestive heart failure exacerbation
  
• Hepatic dysfunction, with elevated liver enzymes

Administration and Monitoring

Diltiazem Hydrochloride Injection should be administered by healthcare professionals experienced in intravenous drug administration and cardiovascular management. Patients receiving the drug should be monitored for blood pressure, heart rate, and conduction interval changes. Continuous ECG monitoring is recommended in the acute care setting to detect significant bradycardia or heart block onset. Liver and kidney function tests should be considered for those receiving prolonged therapy, especially in patients with preexisting hepatic or renal impairment. Adjust dosages accordingly to achieve the desired therapeutic effect with minimal adverse reactions.