Hylenex Injection Recombinant Hyaluronidase (Rx) **Refrigeration Item
(Note: We don’t Fill Personal Prescriptions)
How to Order:
You will receive instructions on how to create an account along with Rx Ordering Details.
Hylenex Injection is a brand name for hyaluronidase, an enzyme that temporarily breaks down hyaluronic acid in the body, increasing tissue permeability. This helps fluids and medicines injected under the skin (subcutaneously) to spread more easily and be absorbed more rapidly.
Note: Refrigerated Item, Ships Next Day Air, Signature Required Someone must be available to receive this shipment.
Common Uses of Hylenex Injection:
-
Facilitating subcutaneous fluid administration: In situations like dehydration, especially in children, Hylenex is sometimes used to make it easier and faster to infuse subcutaneous fluids (sometimes called “hypodermoclysis”).
-
Enhancing absorption of injected drugs: When medications that are usually given under the skin (like insulin or morphine) need faster absorption, Hylenex can be mixed with the drug.
-
Improving imaging procedures: Sometimes used during certain diagnostic radiology procedures to improve the spread of contrast agents.
-
Extravasation management: Can be used to help disperse drugs that have accidentally leaked into the tissue during IV administration.
How It's Given:
- Form: Injectable solution.
- Route: Injected under the skin (subcutaneously).
- Dosing: Depends on the purpose (always follow healthcare provider’s instructions).
Key Points & Precautions:
- Not for intravenous injection by itself.
- Not a standalone treatment: Only used as an adjuvant or facilitator, not as a therapeutic agent itself.
- Allergic reactions to hyaluronidase are possible (rare).
- Not effective with some tissue-damaging drugs (certain chemotherapy agents).
Side effects:
- Swelling or itching at the injection site.
- Allergic reactions (rash, difficulty breathing – rare).
- Redness or warmth at the injection site.
Contraindications:
- Allergy to hyaluronidase.
- Infections or tumors at the injection site.
Where do you inject Hylenex?
Hylenex is injected subcutaneously, which means just under the skin. It is commonly administered in the following areas:
- Abdomen: Often around the stomach area, avoiding the navel.
- Upper Arm: The outer aspect of the arm provides an accessible location.
- Thighs: Typically the front aspect, where there is more subcutaneous tissue.
The specific site may depend on the treatment plan and the patient's needs. It's important to follow medical guidance for proper injection technique and site selection. Always consult a healthcare professional for precise instructions.
How much Hylenex does it take to dissolve fillers?-
Amount of Filler: The volume of filler that needs to be dissolved impacts the required dosage.
-
Type of Filler: Different hyaluronic acid fillers may have varying cross-linking densities, affecting how easily they dissolve.
-
Area Treated: Certain areas may require more precise applications and, therefore, varying amounts of Hylenex.
-
Desired Outcome: The extent of correction or reversal required will also influence the quantity used.
Typically, a practitioner will start with a conservative amount and assess the effect, possibly requiring multiple sessions for optimal results. It's essential for these injections to be administered by a qualified professional to determine the appropriate dosage for each individual case.
How much does Hylenex cost?Formulation: Hylenex is supplied as a clear, colorless, sterile liquid solution in a 1 mL vial containing 150 units/mL of recombinant human hyaluronidase.
Administration: Typically administered subcutaneously as part of other therapies to enhance drug absorption.
Storage: Hylenex should be stored refrigerated at 2-8°C (36-46°F).
Mechanism of Action:
Hylenex works by temporarily breaking down hyaluronic acid, a component of the extracellular matrix in tissues. Hyaluronic acid forms a barrier to the diffusion of fluids, so by decreasing its viscosity, Hylenex enhances the permeability of subcutaneous or connective tissue. This action enables faster absorption and spread of co-administered drugs or fluids injected under the skin.