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Marcaine (Bupivacaine Hydrochloride) 0.75% Injection 10 mL Vials, 10/pack (Rx)

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Original price $ 129.95
Current price $ 92.00
SKU 00409-1582-10
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Marcaine (Bupivacaine Hydrochloride) 0.75% Injection is a local anesthetic used to provide long-lasting pain relief during surgical, dental, and obstetric procedures. It works by blocking nerve signals in specific areas of the body, preventing the sensation of pain. Marcaine is particularly effective for regional anesthesia techniques such as epidurals, nerve blocks, and spinal anesthesia, making it ideal for managing pain in complex procedures, labor and delivery, and postoperative recovery.

Details and Features

Active Ingredient: Bupivacaine Hydrochloride
Concentration: 0.75% (7.5 mg/mL)
Volume: 10 mL per vial
Packaging: 10 vials per pack
Formulation: Sterile solution for injection
Usage: Used for local or regional anesthesia during surgeries, dental procedures, or chronic pain management.
Manufacturer: Pfizer Injectables

Mechanism of Action

Bupivacaine works by binding to and inhibiting voltage-gated sodium channels on nerve cells. This action blocks nerve impulse generation and propagation, thereby providing a local anesthetic effect. Bupivacaine has a longer duration of action compared to other local anesthetics, making it particularly useful for prolonged surgical procedures or pain relief.

Warnings

  • Cardiovascular Risks: Potential for cardiovascular complications including hypotension and arrhythmias; use with caution in patients with cardiovascular disease.
  • Central Nervous System Effects: Risk of central nervous system toxicity, including seizures, especially if administered intravascularly.
  • Allergic Reactions: Rare potential for hypersensitivity reactions; contraindicated in patients with known allergies to amide-type anesthetics.
  • Pregnancy: Should be used cautiously in obstetric anesthesia due to potential effects on the mother and fetus.
  • Injection Technique: Must be meticulously administered to avoid accidental intravascular injection.
  • Contraindications: Avoid use in intravenous regional anesthesia (Bier block).

Side Effects

Common Side Effects:

  • Local irritation at the injection site
  • Dizziness
  • Nausea or vomiting
  • Sensations of tingling or numbness

Serious Side Effects:

  • Cardiovascular: Arrhythmias, bradycardia, cardiac arrest
  • CNS Toxicity: Seizures, confusion, nervousness
  • Respiratory distress: Difficulty breathing in severe cases
  • Allergic Reactions: Urticaria, rash, or anaphylactic reactions

Administration and Monitoring

Marcaine should be administered by healthcare professionals experienced with regional anesthesia and the management of potential complications. Continuous monitoring of the patient's cardiovascular and respiratory status is advised during administration. Emergency resuscitative equipment and medications should be immediately available in case of adverse reactions. Dosage should be tailored to the individual needs of the patient and the specific procedure being performed, taking special care in patients with underlying health conditions that may influence their reaction to the drug.

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