Sodium Bicarbonate For Injection 8.4%, 50 mL Vials 25/pack (Rx)

Sodium Bicarbonate for Injection 8.4% is used to treat metabolic acidosis, a condition where there is too much acid in the body fluids. It works by neutralizing excess acid and restoring the body's pH balance. This injection is critical in emergency settings, such as cardiac arrest, severe kidney failure, or drug overdoses, where rapid correction of acidosis is needed. It may also be used to alkalize the urine in certain medical conditions, enhancing the excretion of toxic substances and improving patient outcomes.

Sodium Bicarbonate for Injection 8.4% by Pfizer Injectables is a sterile, intravenous solution used primarily for the treatment of metabolic acidosis and certain drug intoxications. Each 50 mL vial is carefully formulated to provide an effective therapeutic concentration of sodium bicarbonate in clinical settings, where rapid correction of acid-base balance is necessary. Packaged in convenient 25-pack vials, it is an essential component in hospital emergency rooms and intensive care units.

Details and Features:

• Concentration and Formulation: Each 50 mL vial contains 8.4% sodium bicarbonate (equivalent to 1 mEq/mL), providing an effective concentration for intravenous administration.
  
• Packaging: Supplied in a pack of 25 vials, ensuring ample stock for medical institutions requiring frequent use.
  
• Sterile and Ready-to-Use: The solution is sterile and pyrogen-free, ready for immediate intravenous use in critical situations demanding urgent care.
  pH Buffer: Functions as an effective alkalizing agent to correct acidosis and improve patient outcomes in emergencies.

Mechanism of Action:

Sodium bicarbonate acts as a systemic alkalizer by dissociating into sodium and bicarbonate ions upon administration. The bicarbonate ions buffer excess hydrogen ions, elevating blood pH, and thereby effectively counteracting acidosis. This neutralization of excess acid in the blood helps restore normal acid-base balance, facilitating improved cellular function and overall physiological stability.

Warnings:

• Electrolyte Imbalance: Overuse or rapid administration of sodium bicarbonate can lead to metabolic alkalosis and electrolyte disturbances such as hypokalemia and hypernatremia.
  
• Cardiac Symptoms: Patients with pre-existing heart conditions may be at risk of fluid overload and sodium retention, requiring cautious use.
  
• Renal Impairment: Patients with renal insufficiency should be monitored closely due to the risk of exacerbating electrolyte imbalances.
  
• Monitor Blood Gases: It is crucial to regularly monitor blood pH and electrolyte levels for adjusting dosage appropriately during treatment.

Side Effects:

• Common Side Effects: Possible side effects include abdominal distension, flatulence, and discomfort associated with changes in gastric pH.
  
• Serious Side Effects: May include metabolic alkalosis, edema due to sodium retention, hypernatremia, and hypokalemia, particularly with uncontrolled or rapid administration.
  
• Injection Site Reactions: There is a possibility of irritation or inflammation at the injection site.

Sodium Bicarbonate for Injection 8.4% 50 mL Vials by Pfizer Injectables provides medical practitioners with a reliable option for the quick correction of acid-base imbalances in critical situations. Careful monitoring and adherence to dosing protocols can mitigate risks and enhance clinical outcomes. Always use under the guidance of trained medical professionals.